New research suggests that individuals who stop using popular slimming jabs like Mounjaro or Wegovy may regain reduced body mass far faster than those who end traditional lifestyle plans.
Findings released in a major health publication demonstrates that while obese people often shed about a fifth of their body weight while on the medication, the weight returns at an average rate of nearly a kilo each month after stopping.
"People using such drugs should be cognizant of the risk of fast rebound weight gain when the therapy ends," cautioned lead investigator Dr. Susan Jebb.
Such speed of regain suggests a reversion to original mass within about one and a half years.
Comparing Treatments
The research, which reviewed 37 of trials involving over 9,000 of participants, compared the outcomes of the injectable medications with other pills.
The team point out that individuals who lose weight through diet and exercise typically experience a less rapid creep back—around 0.1 kg a month—after stopping.
Understanding the Quick Rebound
Experts believe the way of the drugs explains the amplified rebound.
These medications mimic a natural hormone called glucagon-like peptide-1, which controls feelings of fullness.
"Artificially providing the hormone concentrations several times higher than the body's typical production might result in the system to produce less of its endogenous GLP-1, and could reduce sensitivity to its actions," explained Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this hormone supplement means hunger is uncontrolled, making overeating a significant risk."
A Lifelong Condition?
Health authorities recommend the injections for individuals with obesity-related health risks, alongside prescribed lifestyle changes.
Many experts contend that, due to the high risk of weight regain, the treatment is often life-long.
This opinion is echoed by drug manufacturers, who say that the findings "highlight the persistent character of obesity," comparing it to managing conditions like hypertension.
User Accounts
People who have discontinued the jabs explain a sudden resurgence of cravings.
"I experienced something activating and I was suddenly ravenous," said an individual.
The struggle is compounded if users have not adopted sustainable dietary or behavioural changes during therapy.
Widespread Use
Figures indicate that millions of people in the UK have tried weight-loss jabs in the past year, with demand continuing to grow.
- Adoption is more common among females than males.
- The 40s and 50s age group shows the highest level of interest.
- Many access the drugs through private prescriptions rather than the NHS.
In conclusion, researchers caution that while the jabs are powerful agents for shedding pounds, they are not a permanent solution and long-term success hinges on combined lifestyle support.
